In some cases, an active drug is made inactive (or less active) through metabolism. Genelex currently tests for 25 genes to help understand how medications may interact with them. CONTACT US (800) 837-8362 info@genelex.com. Our high-complexity laboratory facilities feature: Robotic DNA extraction and testing, to ensure high accuracy and low error; Proprietary test platforms and methodologies; Testing for more allele mutations than any other system; Test validation across multiple platforms There are several known genes which are largely responsible for variances in drug metabolism and response. FAQs Contact Us Lab Accreditations Genelex's pharmacogenetic testing bridges the gap in understanding how the role of PGx can help in patient care and offers a simple DNA test and provides you with a report of the results that you and your doctor can discuss. (Includes major drug metabolizing enzymes) CYP3A4, CYP3A5, CYP2C9, CYP2C19, and CYP2D6, ADRA2A, CYP1A2, CYP3A4, CYP3A5, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP4F2/VKORC1, COMT, DPYD, F2 (Factor II), F5 (Factor V) Leiden, GRIK4, HLA-A, HLA-B, HTR2A, HTR2C, IFNL3 (IL28B), MTHFR, NAT2, OPRM1, SLCO1B1, TPMT, UGT1A1. Patients should not alter their medication regimen unless directed to do so by a health care provider. Approximately 7% of the population has a slow acting form of this enzyme and 7% a super-fast acting form. One variation example is CYP2D6. Privacy Practices Note: Per the recent FDA safety communication issued October 31 2018, patients will receive patient-friendly reports that include only those genes approved by the FDA and listed in their Table of Pharmacogenomic Biomarkers. Studies have shown that integrating information from pharmacogenetic testing into the drug prescribing process can … The testing process includes pharmacist review, patient- and clinician-facing reports, as well as access to clinical decision support for the treating provider. These standards include: More than 85% of patients have significant genetic variations in the most important cytochromes [70] – CYP2D6, CYP2C9, CYP2C19, CYP3A4 and CYP3A5. Major pharmacogenetic strides over the past decade have led the way to leveraging genetic information to guide therapies for cardiovascular patients. Genelex's pharmacogenetic testing platform offers a comprehensive suite of tools to help healthcare providers personalize medication regimens based on a patient’s genetics. CYP2D6 acts on 25% of all prescription drugs. The Genelex self-service portal provides you with the tools to understand how your medications interact with each other and with your genes. Genelex has been a leader in molecular diagnostics and genetic testing for more than 30 years, with a specialty focus on pharmacogenetics. The challenge in drug therapy is to make sure that the active form of a drug stays around long enough to do its job. Valerie Baron is an employee of YouScript, which created the clinical decision support tool used in this study and formerly was part of Genelex. Genelex has been a leader in pharmacogenetic testing since 2000. Genelex offers pharmacogenetic testing that analyzes the genes that are important for understanding variation in how people metabolize and respond differently to prescription medications. [94,95] In the second mechanism, an individual clinical laboratory develops and offers a test. Drug-metabolizing enzymes. Several test labs market panels of tests or individual tests designed to address one or more aspects of pain management, including but not limited to drug selection, drug dosing, or prediction of AEs. The use of YouScript's software, in combination with Genelex pharmacogenetic testing, has been shown to reduce adverse events, costs and hospital readmissions in peer-reviewed published studies. The focus of this article will remain on the genes that are more widely accepted and utilized clinically for brevity. Pharmacogenetic testing. Footer. Clinical trials to date have suggested testing might be most beneficial for individuals who have experienced an adverse drug reaction or inadequate response to a previous antidepressant trial. Pharmacogenetic testing is the alternative to “one size fits all” and “trial and error” prescribing. Serotonin is a neurotransmitter, a chemical that transmits signals from one nerve cell to another, and changes in the levels of this chemical … Health care providers will receive a comprehensive 25 gene report that includes a pharmacist reviewed medication management section. CONTACT US (800) 837-8362 info@genelex.com. Knowledge of patient drug metabolizing gene variants—found in more than half of patients—can help determine the appropriateness and dosage of … Genelex Team [6,33], 3101 Western Ave. HIV therapy is known to be associated with a large variability in efficacy and toxicity among different individuals even at standard doses. Commercially Available Genetic Tests for Pain Management. This relatively new field combines pharmacology (the science of drugs) and genetics(the study of genes and their functions) to potentially develop effective, safe medications and doses that will be tailored to … This includes information for over 40 genes, but does not provide information about specific drugs or drug classes. Trial was sponsored by genelex ( Clinicaltrials.gov ID number NCT02428660 ) respond differently to prescription medications understanding in! On 25 % of all prescription drugs Privacy Practices Privacy Policy acting form a... 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